With the focus shifting to R&D and manufacturing of biotech-based drugs,
its good news for biotechnology professionals.
Winds of change are blowing through the Indian pharmaceutical industry. More
and more pharma companies are looking at biotech-based pharma products.
Restructuring is the buzzword. Following news snippets in the last two months
will give indications on the hiring-mart.
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Nicholas Piramal India Ltd, a BioSpectrum Top 20 company
and one of the leading pharmaceutical healthcare companies in India, is
expanding its operations and recruiting another 100 scientists.
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Torrent Pharma, an Ahmedabad-based pharma major is
recruiting 100 scientists taking its total strength within the company from
190 to 290.
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Zydus Cadila, another Ahmedabad-based healthcare
solutions company with a strong base of 200 scientists, is adding another
100 scientists to its team.
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Alembic Ltd, a Baroda-based pharma company, has planned
to increase the number of scientists on its rolls from 100 to 250,
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Similarly, Cadila Pharmaceuticals plans to increase its
strength from 150 to 200.
The trend is completely in favor of increased activity in
bio-pharma. The marked change in human resource development initiatives is not
hard to comprehend. In view of the forthcoming products patents regime, pharma
companies have identified R&D as one of the key growth drivers. With a high
premium on R&D and many new avenues such as clinical research, contract
research, developing new drug delivery systems and new chemical entities opening
up before the Indian pharma companies, the demand for qualified trained
professionals in related fields is growing. Not just the Indian companies, but
several MNCs are looking at India to set shop to gain the cost, time, and the
trained manpower advantage as R&D costs in their home countries are very
high.
Dr SD Ravetkar, senior director, Serum Institute of India,
said, "The potential for Indian BioPharma segment is huge. With the
implementation of WTO and patents regime in 2005, Indian companies would not be
able to do backward engineering of the drugs, so they are focusing on in-house
R&D. The growth prospects are bright as many contract research organizations
are coming up. Besides, a large number of foreign pharma companies are setting
their R&D divisions here." Serum Institute is one of the largest
exporter of vaccines and immunobiologicals of the country with its products
being exported to about 38 countries across the globe.
"The sector calls for professionals from various fields
as biopharma is the cocktail of so many faculties—microbiology, biochemistry,
molecular biology, immunology, chemistry, biotechnology and more. It requires
candidates with diverse qualifications—microbiologists for the manufacturing
process, biochemists for the down stream processing, immunologists for animal
trials, biotech engineers for bulk manufacturing processes or process
standardizing, etc." he added.
What are they looking for?
Traditional pharmacology is increasingly being considered as
the downstream processing of biotech-based pharma. With this change in focus,
the requirements of pharma companies at the entry level are also changing.
Besides, regular pharma graduates and postgraduates, the industry is looking
towards MSc and PhD candidates possessing specialized knowledge. The field
requires people trained in new technologies with specialized skills, like
immunoblotting, protein/genome analysis, western blotting etc. And in today’s
scenario candidates possessing these skills are rare. The responsibility and
specialization of the individual will depend on the process, which he or she is
handling—fermentation technology, downstream processing, proteomics, genomics,
etc.
"We are looking at people with a good background in
biotechnology, biochemistry, or microbiology. Some basic technical skill is a
must. At the same time they should have good understanding and reasoning
capabilities, in addition to good communication skills and the ability to
understand scientific literature," said Dr Shama Bhat, chairman and
managing director, Bhat Biotech, a nine year old Bangalore-based biotech company
specializing in design development, manufacture and marketing of diagnostic test
devices for various types of tests like hepatitis, pregnancy, HIV.
Varaprasad Reddy, CMD, Shantha Biotechnics, further
elaborated, "The biotech industry is a knowledge-intensive one and human
resource is its prime asset and strength. Quite like the IT sector was in the
early Nineties, the biotech sector too is witnessing a lot of hype leading to
expectations and is definitely a sunrise sector for any job-seeker. Hence, there
is demand for qualified and experienced personnel. For the R&D job seeker,
what is needed is the right exposure to the scientific way of working and the
mindset to experiment and innovate. And patience to see R&D translate into
commercial success.
For
people wishing to enter into other functions like sales and marketing, it would
be easier as experience in a good pharmaceutical or FMCG company backed by an
MBA qualification would be good enough. Also doctors wishing to enter the
corporate world can find opportunities in Clinical Trials and be responsible for
conducting trials and regulatory approvals."
Clearly R&D, manufacturing and production, and sales and
marketing are the main job categories in the Biopharma field. The importance of
R&D is obvious and proper manufacturing is equally important so as to
confirm to the international standards of cGMP. Also since most of the products
are targeted at the global markets, they should conform to the export
specifications. According to Dr Ravetkar ideally the distribution of manpower in
companies developing new biotech-based cures should be equal in both research
and manufacturing. "The main thrust of most companies is towards these two,
while marketing and sales form the smaller divisions. This is because at present
this field being new, products being less, there is little competition. The main
challenge is R&D and manufacturing of the product rather than marketing the
product," he said.
For companies dealing in the diagnostics market, marketing is
an equally important field due to the higher number of products in this sector.
For example in Bhat Biotech the distribution of employees across the categories
is about 50 percent in research, 30 percent in production and 20 percent in
marketing.
How are companies recruiting?
For recruiting candidates at the entry level, most companies
advertise in the leading national dailies or in the careers/jobs section on
their websites. After the resumes are received candidates are short-listed
through one-to-one interviews or sometimes written tests followed by an
interview. Some companies arrange for walk-in interviews or go for campus
recruitment also. "We also go for campus recruitment in Pune University,
Hyderabad University and Bombay University. In the interview we mainly consider
the attitude of the student. There are three important points that we keep in
mind while selecting candidates: their basic qualification, any additional
courses they have done, which adds value like bioinformatics or courses in
bioinstrumentation. And good project work," elaborated Dr Ravetkar.
"Basically the students should possess a
basic/fundamental science degree and then do some supportive course. We have
found another efficient method of selection—by absorbing candidates who come
to do their MSc dissertation projects at Serum Institute. This way we get to
know the students better, work with them at close quarters and are thus are able
to assess them better. Sometimes we have seen that though their (students)
academic results are not very good but they have a flair for R&D and do good
research work. Another important consideration is good communication ability and
confidence in oneself."
A common advice by pharma majors to aspiring candidates is to
hone their skills. As, ironically on one side, the sector has a requirement of a
large number of people and on the other hand there is an acute dearth of
adequately trained students. Most of them do have a strong theoretical
background but do not possess enough practical skills. Students need to gain
hands-on experience in the new upcoming branches of science. It is not that
companies are not willing to train but the cost of training in terms of time is
high. On an average investing in human capital, i.e., training a fresh person
requires about a year, which also many a times goes waste when they go for
greener pastures. Thus a minimum work experience of two to three years is
gaining priority and provides a crucial selection edge.
Further, several of the leading companies believe that the
science colleges should try and make their students the best just like the
management colleges, which promote their students. Like management companies,
they should also invite premier companies for campus recruitment. They should
invest in training and guiding the students.
The salaries of researchers in pharma companies are
appropriate, merit based and have begun to reflect the growing demand for
skilled people. "The PhDs get remuneration in the range of Rs 5 lakh and
above per annum," said Reddy. The growth potential for employees is good,
as it is a nascent industry. Generally employees who perform well are sent for
technology development training programs both in the country and abroad, like
Serum Institute sends its employees to the US and UK for training in cGMP and
production techniques.
As developing new biotech-based solutions has become the main
focus area for the pharma companies the demand for the scientists is expected to
continue to grow. The characteristics of this business as opposed to those in
other biotech segments like bioagri and bioinformatics is different too. Reddy
explained, "This business is highly capital-intensive and needs a lot of
R&D focus. Since development times are higher for biotech products, the
employees need to have focus and motivation as well as determination to see the
product through to market. Also since regulatory framework is not very
industry-friendly, a lot of effort is needed for clearances and approvals."
Finally, there are no stereotypes in the biotech world, except for the desire to
make an impact on the world of disease.
Rolly Dureha
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Shantha Biotech employs people with a wide range of
qualifications such as diplomas, MSc, MBA, M Tech, PhD in functions like
research, manufacturing, quality assurance, clinical research, sales and
marketing.
Some sample posts and qualifications:
Head, Protein Sciences
PhD in protein chemistry/molecular biology/biochemistry. Over five
years experience in industry. Manages a group of 6-10 scientists and
research associates and have experience in managing all aspects of protein
expression and purification for research use.
Protein Expression and
Refolding Scientist
PhD or MS in biochemistry or related field.
Pharmaceutical or biotech industry experience preferred. Experience in E.
coli expression, refolding, or related research field. Experience in
bacterial expression and isolation of inclusion bodies. Experience in
refolding proteins from inclusion bodies. Basic bioinformatics skills for
manipulating DNA and protein sequences. Basic skills in protein
purification and characterization, machine operation of FPLC, HPLC and
PAGE.
A research associate
is responsible for research and development in
collaboration with others on projects. He/she makes detailed observations,
analyzes data, and interprets results. Research associates prepare
technical reports, summaries, protocols, and quantitative analyses. An
incumbent maintains familiarity with current scientific literature and
contributes to the process of a project within his or her scientific
discipline, as well as investigating, creating, and developing new methods
and technologies for project advancement. He/she may also be responsible
for identifying patentable inventions and acting as principal investigator
in conducting his or her own experiments.
A quality control analyst
is responsible for conducting routine and non-routine
analysis of raw materials. He/she compiles data for documentation of test
procedures and reports abnormalities. A quality control analyst also
reviews data obtained for compliance with specifications and reports
abnormalities. He/she revises and updates standard operating procedures
and may perform special projects on analytical and instrument problem
solving. An entry-level quality control analyst’s position requires a
Bachelor of Science degree in a scientific discipline or equivalent and a
minimum of 0-2 years’ experience in quality control systems.
A clinical research associate
is responsible for the design, planning,
implementation, and overall direction of clinical research projects.
He/she evaluates and analyzes clinical data and coordinates activities of
associates to ensure compliance with protocol and overall clinical
objectives. He/she may also travel to field sites to supervise and
coordinate clinical studies. An entry-level clinical research associate
position typically requires a bachelor of science, a registered nurse
degree or equivalent, and a minimum of 0-2 years’ clinical experience in
medical research, nursing, or the pharmaceutical industry. Knowledge of
regulatory requirements is also preferred.
A clinical coordinator
must be familiar with the scientific/investigative
process. Expertise may be limited to a specific functional area. A
clinical coordinator must have good communications skills, both written
and oral. He/she must also have project team experience and a familiarity
with standard computer applications. Responsibilities include coordinating
the clinical development plan as outlined by the company or Clinical
Department, defining objectives, strategy, and studies. The clinical
coordinator must provide support for planning, including detailed effort
estimates, scheduling, and critical path analysis. He/she must monitor
clinical activities to identify issues, variances, and conflicts, and
analyze and recommend solutions.
A regulatory affairs
specialist
at the entry level, coordinates and prepares document packages for
submission to regulatory agencies, internal audits, and inspections.
He/she compiles all material required for submissions, license renewals,
and annual registrations. An incumbent monitors and improves tracking and
control systems and keeps abreast of regulatory procedures and changes.
He/she may work with regulatory agencies and recommend strategies for
earliest possible approvals of clinical trial applications.
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Rolly Dureha
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